Differential Translation of Dazap1 Transcripts during Spermatogenesis
نویسندگان
چکیده
منابع مشابه
Differential Translation of Dazap1 Transcripts during Spermatogenesis
Deleted in AZoospermia Associated Protein 1 (DAZAP1) is a ubiquitous hnRNP protein that has been implicated in RNA transcription, splicing, and translation. It is highly expressed in testes, predominantly in late stage spermatocytes and post-meiotic spermatids. Dazap1 deficiency in mice results in growth retardation and spermatogenic arrest. The gene produces two major transcripts of 2.4 and 1....
متن کاملDAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation.
DAZ-associated protein 1 (DAZAP1) is an RNA-binding protein required for normal growth, development, and fertility in mice. However, its molecular functions have not been elucidated. Here we find that Xenopus laevis and human DAZAP1, which are each expressed as short and long forms, act as mRNA-specific activators of translation in a manner that is sensitive to the number of binding sites prese...
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Deleted in Azoospermia Associated Protein 1 (DAZAP1) is a ubiquitous heterogeneous nuclear ribonucleoprotein (hnRNP) that is expressed abundantly in the testis. DAZAP1 deficiency in mice results in growth retardation and spermatogenic arrest. Previous reports on DAZAP1's binding to several naturally occurring splicing mutations support a role for DAZAP1 in RNA splicing. To elucidate the biologi...
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At the request of the USG National Virtual Translation Center, the University of Maryland Center for Advanced Study of Language conducted a study that assessed the role of several factors mediating transcript usefulness during translation tasks. These factors included source language (Mandarin or Modern Standard Arabic), native speaker status of the translators, transcript quality (low or moder...
متن کاملDifferential histone modifications mark mouse imprinting control regions during spermatogenesis.
Only some imprinting control regions (ICRs) acquire their DNA methylation in the male germ line. These imprints are protected against the global demethylation of the sperm genome following fertilisation, and are maintained throughout development. We find that in somatic cells and tissues, DNA methylation at these ICRs is associated with histone H4-lysine-20 and H3-lysine-9 trimethylation. The u...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0060873